Initial Resection of Primary Lesion(s) for Cushing's Agent Skill

Recommends initial surgical resection of the primary lesion(s) causing Cushing's syndrome when surgery is feasible and likely to…

Context cost
725 tokensestimated from the bundle, loaded when it triggers
Bundle
1 file · 2.9 kBtext throughout, nothing executable
Licence
not declarednone named by its author
Last change
—no release on file
Servers it uses
Noneruns standalone

What it does

Recommends initial surgical resection of the primary lesion(s) causing Cushing's syndrome when surgery is feasible and likely to significantly reduce glucocorticoid excess. Trigger phrases include overt Cushing's syndrome, ACTH-dependent CS, ectopic ACTH secretion, adrenal adenoma, bilateral macronodular adrenal hyperplasia, and persistent hypercortisolism.

What this skill changes about the agent has not been set out here as a list. Its SKILL.md, shown below, says it in the author’s own words.

documentation

The skill itself

A skill is instructions the model reads, so you can see what you are getting: below is the start of its SKILL.md. The front matter loads with every session, the body loads when the skill triggers, and the whole file comes with the install.

SKILL.md2.9 kB · preview
--- name: es-cushing-initial-resection-recommendation ---
6# Initial Resection of Primary Lesion(s) for Cushing's Syndrome
7
8## STEP 1 — Gather Information
9Confirm overt Cushing's syndrome via abnormal cortisol excretion (UFC, late-night salivary cortisol, dexamethasone suppression) and determine etiology: pituitary MRI for ACTH-secreting tumor, chest/abdominal imaging for ectopic source, adrenal CT/MRI for adrenal lesion; assess surgical feasibility and likelihood of significant glucocorticoid reduction.
10
11## STEP 2 — Rule In / Rule Out
12Is surgery possible and likely to significantly reduce glucocorticoid excess? If no, proceed to second-line therapies (medication, bilateral adrenalectomy, radiation). If yes, move to classification.
13
14## STEP 3 — Classify or Stratify
15Classify by etiology: pituitary Cushing's disease -> transsphenoidal selective adenomectomy (TSS); ectopic ACTH-secreting tumor -> localization and resection with node dissection; benign unilateral adrenal adenoma/carcinoma -> unilateral adrenalectomy; bilateral macronodular adrenal hyperplasia (BMAH) -> consider bilateral adrenalectomy if aberrant hormone receptors demonstrated, otherwise medical therapy; adrenal carcinoma -> resection if resectable, else consider adjuvant therapy.
16
17## STEP 4 — Decide
18Perform the indicated primary lesion resection by an experienced surgeon (adrenal, pituitary, or thoracic/abdominal as appropriate) with goal of normalizing cortisol levels or action.
19
20## Clinical Guardrails / Mimics / Pitfalls
21Do not resort to surgery if it is unlikely to significantly reduce glucocorticoid excess (e.g., diffuse ectopic disease, unresectable carcinoma); avoid mistaking ectopic source for pituitary lesion without proper localization; ensure surgeon expertise to minimize complications; do not proceed with bilateral adrenalectomy for BMAH without evidence of aberrant receptor coupling; monitor for postoperative adrenal insufficiency and provide glucocorticoid replacement as needed.
22
23## Concrete Clinical Example
24A 48-year-old man presents with overt Cushing's syndrome, elevated UFC and loss of diurnal rhythm; pituitary MRI reveals 8 mm microadenoma, inferior petrosal sinus sampling confirms central ACTH source; he undergoes transsphenoidal selective adenomectomy by an experienced pituitary surgeon; postoperative morning cortisol normalizes within 2 weeks, achieving remission.
This is a preview of SKILL.md. Download or install the skill to get the whole thing.
In the file
SKILL.md364 words
Files1
Licencenot declared
Why you can read it

Nothing in a skill executes. The client loads the text and the model follows it, so a skill can be audited the way a runbook is — by reading it.

What it costs in context

Skills are not billed by the call. They are paid for in context: every token the instructions occupy is a token your code, your diff and your conversation cannot use. Here is what this one takes and when it takes it.

≈110
always loaded
The name and description, so the model knows the skill exists and when to reach for it.
615
on trigger
The instruction body, read only when the skill fires.
0.36%
of a 200k window
Ten skills this size would take about 4% of the window before you open a file.
050k100k150k200k context window

725 tokens, estimated from the bundle at four bytes to the token, held for the rest of the session once it triggers. Small enough to keep loaded permanently without thinking about it.

Servers bill, skills cost

A server charges by the month. A skill charges once per session, in context, and then keeps charging it for as long as the session lives.

Before and after

The same question, put to the same model twice: once as it comes, and once with these instructions loaded.

No worked example has been published for this skill yet.

The procedure it runs

The procedure has not been set out here step by step. It is in the body of its SKILL.md: the start of it is shown above, and the whole file comes with the install.

Prose, not code

These steps are written for a model to follow, not executed by a runtime. It can still be told to skip one, and it will say so when it does.

Servers it uses

None. This skill calls no MCP servers at all.

Everything it needs is in the instructions, so it works in a project with nothing connected — the model reads the file and changes how it works with what it can already reach.

Its SKILL.md does not declare which tools it asks the agent for, so what it touches is whatever the instructions themselves ask for — read them before you install it.

What it asks for
Writes filesnot declared
Network accessnot declared

This SKILL.md carries no allowed-tools line, so neither is declared. A skill grants no permissions of its own — it can only ask for tools your client already has.

What it will not do

Every skill is narrow, and the useful ones say where they stop. These are the jobs this one is the wrong tool for.

What this skill is not for has not been published here. Nothing is implied by that: it is a section the author has not filled in.

What is in the bundle

1 file, 2.9 kB on disk. A bundle is text throughout: the instructions the model reads, plus the templates it fills in.

  • SKILL.md2.9 kB
What is not in it

No dependencies and nothing executable: a skill is text the agent reads, so the bundle is 1 file you can review in full before installing.

Install

Installing copies the bundle into your project. Nothing runs at install time — the files sit on disk until the model reads them.

# Initial Resection of Primary Lesion(s) for Cushing's · 725 tokens when loaded · macOS, Linux mkdir -p .claude/skills && t=$(mktemp -d) && curl -fsSL -o "$t/bundle.tar.gz" https://mcprush.com/api/skills/initial-resection-of-primary-lesion-s-for-cushing/bundle.tar.gz && tar -xzf "$t/bundle.tar.gz" -C "$t" && [ -d "$t/initial-resection-of-primary-lesion-s-for-cushing" ] && { [ ! -e .claude/skills/initial-resection-of-primary-lesion-s-for-cushing ] || { mv .claude/skills/initial-resection-of-primary-lesion-s-for-cushing "$t/.previous" && echo "Previous copy moved to $t/.previous"; }; } && mv "$t/initial-resection-of-primary-lesion-s-for-cushing" .claude/skills/ && echo "Installed .claude/skills/initial-resection-of-primary-lesion-s-for-cushing"
On Windows, or any OS with Node 20+
npx mcprush@latest skill add dromlakhani/initial-resection-of-primary-lesion-s-for-cushing

Windows PowerShell says 'running scripts is disabled on this system'? Run Set-ExecutionPolicy -Scope CurrentUser RemoteSigned once, or type npx.cmd instead of npx (codex.cmd, gemini.cmd, grok.cmd likewise). PowerShell 7 needs neither. Writes to .claude/skills/initial-resection-of-primary-lesion-s-for-cushing/ in the current project. For every project instead, run mkdir -p ~/.claude/skills && t=$(mktemp -d) && curl -fsSL -o "$t/bundle.tar.gz" https://mcprush.com/api/skills/initial-resection-of-primary-lesion-s-for-cushing/bundle.tar.gz && tar -xzf "$t/bundle.tar.gz" -C "$t" && [ -d "$t/initial-resection-of-primary-lesion-s-for-cushing" ] && { [ ! -e ~/.claude/skills/initial-resection-of-primary-lesion-s-for-cushing ] || { mv ~/.claude/skills/initial-resection-of-primary-lesion-s-for-cushing "$t/.previous" && echo "Previous copy moved to $t/.previous"; }; } && mv "$t/initial-resection-of-primary-lesion-s-for-cushing" ~/.claude/skills/ && echo "Installed ~/.claude/skills/initial-resection-of-primary-lesion-s-for-cushing" (macOS, Linux) — or add --global to the npx line. The curl line replaces .claude/skills/initial-resection-of-primary-lesion-s-for-cushing/ only after the download succeeds, so files left there by another skill of the same name, or by an older release, do not mix in. A copy already there is moved aside, not deleted, and the line prints where. It appears as es-cushing-initial-resection-recommendation in Gemini CLI, Codex, Copilot and Grok (its own name); Claude Code lists it by the folder name, initial-resection-of-primary-lesion-s-for-cushing.

Which clients pick it up on their own

A skill is a folder of text. Most of these read a skills folder and pick it up without being told; the rest take the same folder another way — an upload in the app, a parameter on an API call — and then choose it by its description just the same.

Claude Code.claude/skills/
Claude DesktopCustomize › Skills
ChatGPTSkills › Create › Upload
Cursor.cursor/skills/
VS Code.github/skills/
Codex CLI.agents/skills/
Gemini CLI.gemini/skills/
Grok Build.grok/skills/
Microsoft CopilotSkills › Upload a skill
PerplexityComputer › Skills › Upload a skill
DeepSeek Harness.dsh/skills/
Zed.agents/skills/
Devin Desktop.devin/skills/
Windsurf (legacy).windsurf/skills/
OpenAI Agents SDKInstructions or sandbox Skills
HTTP / APIa request parameter
This release
Versionnot versioned
Publishedno release date on file
PriceFree
Referencedromlakhani/initial-resection-of-primary-lesion-s-for-cushing

Versions

Its author publishes no version number, so there is nothing here to pin to: what you install is the folder as it stands today. Instructions change more often than APIs do — a skill can be rewritten entirely without anything it depends on moving.

Pinning

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Who wrote it

DR
dromlakhani

Publishes on mcprush.

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