Search arXiv papers, download full text, semantic search, citation graphs, and alerts via MCP.
Nothing to run from here
Nullary is installed from its publisher's own source and answers where it runs, so this marketplace is not in the path of a single call. There is no address here to send one to, and a panel that pretended otherwise would be showing you an answer we made up. Install it and call it from your own client — the Installation tab has the entry for each one.
35
tools declared
—
trust score
remote
at its publisher
—
calls last 7d
What it does
Negative results intelligence for drug discovery — query measured failures via MCP.
Quickstart
# 1 — add it to Claude Code
claude mcp add --scope user --transport http nullary-mcp https://mcp.nullary.ai/mcp
# 2 — ask your agent for something these tools do
# search_inactive_compounds, search_failed_selectivity, search_admet_failures and 32 more
Nullary costs nothing on mcprush: there is no plan to choose here, no cap to set and nothing mcprush can bill you for.
Publishernot claimed
MNAll 1 server
mcp.nullary.ai1 server
1 category
Collected from a public index. Nobody has claimed this account, so nothing here was written by its author — claim it if it is yours.
Installation
Where are you running it?
Every route below installs the same thing and ends at the same approval screen. Nothing here runs on your machine and nothing runs on ours: this server answers at its publisher’s own address, and what you install is the connection straight to it.
Claude Codedeclared by this listing
This is a public server: it answers at its publisher’s own address and this marketplace is not in the path. Claude Code registers it in one command; --scope user makes it available in every project. The transport below is http, as the publisher's own manifest declares it.
claude mcp add --scope user --transport http nullary-mcp https://mcp.nullary.ai/mcpReconnect, or start a new session, and the tools appear in the model’s tool list.
Free on mcprush, and it answers at its publisher’s own address: this marketplace is not in the path, so there is no key of ours to hold and no card to add.
What it writes
One config entry pointing straight at the publisher’s own address — this marketplace is not in the path, and nothing from this listing executes on your machine.
What you approve
35 tools, with what each one reads, writes and reaches shown before you agree — the same list on every route above. Read the tool surface.
Tool surface
What the model actually sees. Descriptions are diffed on every release — see version history.
Inactive small-molecule compound-target pairs.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Small molecules that failed selectivity.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Small-molecule ADMET failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Failed/ineffective CRISPR guides.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Non-dependency / failed essentiality screens.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Ancestry-specific CRISPR failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Antibody developability failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Discontinued/terminated clinical antibodies.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Failed peptide therapeutics.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Peptide stability/half-life failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
PROTACs that failed degradation/ternary/permeability.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
PROTAC E3-ligase recruitment / ternary failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
ASOs/siRNAs that failed engagement/developability.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Oligonucleotide delivery failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Failed/terminated vaccines (by pathogen/indication).
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| indication | string | no | disease/indication |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Failed vaccine immunogen designs.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
ADCs that failed at any stage.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
ADC failures attributed to linker chemistry.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Bispecifics that failed at any stage.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Bispecific format/engineering failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
ADMET failures across ALL modalities.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Drug-drug interaction failures.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Approaches that failed for a mechanism (by target).
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Findings that failed to replicate.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Clinical/preclinical safety failures across modalities.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | no | UniProt accession or gene symbol |
| compound | string | no | compound name, ChEMBL ID, or InChIKey |
| outcome | string | no | outcome filter (inactive, failed_safety, terminated, …) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
ALL failed approaches against a target across every modality.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | yes | UniProt accession or gene symbol (required) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
ALL failed approaches for an indication across every modality.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| indication | string | yes | indication (required) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Vaccine + antimicrobial + antibody failures for a pathogen.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| pathogen | string | yes | pathogen name (required) |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| inchi_key | string | no | Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid). |
| chembl_id | string | no | ChEMBL molecule ID, e.g. CHEMBL941. |
| pubchem_cid | integer | no | PubChem Compound ID (CID). |
| tier | string | no | Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails). |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
| offset | integer | no | Number of findings to skip before this page, for pagination (default 0). |
Full provenance + detail for a single finding by id.
| Parameter | Type | Required | Notes |
|---|---|---|---|
| id | string | yes | finding UUID |
Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | yes | gene symbol or UniProt accession (required) |
Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
| Parameter | Type | Required | Notes |
|---|---|---|---|
| family | string | no | target family filter (optional) |
| limit | integer | no | Maximum number of findings to return (1–100, default 25). |
Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
No parameter schema on file.
Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
| Parameter | Type | Required | Notes |
|---|---|---|---|
| target | string | yes | gene symbol or UniProt accession (required) |
Per-modality and per-source coverage stats (honest Phase-1 numbers).
No parameter schema on file.
Free
$0 forever
- Every tool — any call limit is its publisher’s, not ours
- No card, and mcprush charges nothing for it
- Runs at its publisher’s own address — this marketplace is not in the path
- Nothing to cap, because mcprush bills nothing
What counts against your monthly calls
| Tool | Unit | Calls used | Out of the allowance |
|---|
Nothing here is billable: mcprush charges nothing to install Nullary or to call it, at any volume.
Call allowance · this installenforced at the gateway
Monthly allowance, in calls
—
—
Alert at 80% · then the tool returns a normal MCP error
Used this month: —
—Grade not published
No rule-by-rule report on file for this release
Two independent axes, because powerful and malicious are different questions. The grade is threat only. The capability level is blast radius, and it is never a penalty on the grade — it is priced as one subtract-only term in the score, where you can see it.
This listing is an address its publisher runs, and you connect to it directly — this marketplace is not in the path. The scanner reads packages and public source, and an address is neither. So there is no grade — not a withheld one, an unmeasured one.
Release history
This is an address its publisher runs: which release it serves is theirs to choose, so there is nothing here to pin. The history below is for reading; the current release on file is 1.0.1.
1.0.1
undated
latestNo release note was published with this version.
—
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One review per account, from a signed-in account that does not publish this listing. Nothing else is asked — you can say what you think before you install it. Publishers can reply once per review, and a review can be edited or deleted by whoever wrote it.
Sign in to write one
Any signed-in account that does not publish Nullary can review it, once — before installing it or after. A review from an account that has installed it is marked as one.
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